In order to answer clinical as well as scientific and translational questions as precisely as possible, we have established a cooperation of three large university associated intensive care departments in Germany and Switzerland, namely Bonn-Hannover-Zurich.

 

Our experimental interest lies on better understanding processes underlying the pathology of ARDS and septic shock, with a focus on the role of immune dysregulation and endothelial injury.  

 

Clinically, we have initiated numerous retrospective and prospective collaborative studies that both evaluate existing therapeutic approaches in large patient collectives as well as investigate novel treatment options in patients with ARDS and septic shock. A special focus lies on evaluating current state of the art ECMO support as well as novel extracorporeal treatment modalities for septic shock.

 

From a translational aspect, we investigate the role of immune dysregulation and endothelial injury in predicting response to novel treatment options for ARDS and septic shock in a „bedside to bench“ approach.